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COMPARATIVE EFFECT OF AQUEOUS EXTRACT OF MUCUNA PRURIENS AND- TELFAIRIA OCCIDENTALIS ON SOME RED BLOOD CELL INDICES OF WISTER ALBINO RATS. By Akwari, Ada A.

ABSTRACT
The Comparative effect of aqueous extract of Mucuna pruriens and Telfairia occidentalis on some red blood cell indices was investigated in rats. A total of Twenty (20) Wister albino rat strains weighing 174g – 290g were grouped into four of five animals per cage. Group 1 served as the control and received only normal rat feed and water for 21 days, the remaining groups (2-4) served as the experimental group. Group 2- received same as group 1 plus aqueous extract M pruriens (25mg/kgbw once daily); Group 3 received same as group 1 plus aqueous extract T occidentalis (25mg/kgbw once daily) and Group 4 received same as group 1 plus aqueous extract T. occidentalis and M. prurien (50mg/kgbw once daily). At the end of the 21 days, the animals were sacrificed and their blood taken for various haematological analyses. The result showed that aqueous extract of T. occidentalis caused significant increase at (p<0.05) in RBC, PCV, HB, MCHC and RDW while it caused a decrease in MCH and MCV. Also the aqueous extract of M. prurien caused a decrease in RBC, PCV, HB, MCV and MCH when compared with their control and caused an increase in MCHC and RDW. The result also showed that a combined extract administration of T. occidentalis and M. prurien resulted in significant decrease in all the red blood cell indices, increase in MCHC, MCV, MCH and a decrease in RDW. Of the two extracts T. occidentalis caused increase of the red blood cell indices and may be a better blood booster than M. pruriens. Also combined extract administration of the two extract should be discouraged when treating mild to severe blood shortage because it caused reduction in red blood cell indices instead of increase.

Keywords: Haematology, Aqueous, Blood booster, Extract, Comparative

 

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