The antibacterial potentials and phytochemical compositions of Azadirachta indica A Juss, popularly known as neem or dogoyaro in Nigeria was evaluated by various pretreatment procedures using a range of dilution ratios in aqueous and alcoholic solvents on sensitive clinical isolates of Staphylococcus aureus and Escherichia coli. The leaves of A. indica were extracted with aqueous and alcoholic solvents for 2 and 72 hours at varying weight/volume ratios and evaluated for antibacterial activity against test bacteria using the well plate method. Minimum inhibitory/bactericidal concentrations were determined. Phytochemical compounds were also evaluated qualitatively by thin layer chromatography and quantitatively by direct chemical estimation. Ethanolic extracts were more active than methanolic extracts with highest zone size of 22±0.04 against E. coli at the 500mg/ml concentration of freshly decocted extracts compared to 26mm recorded with shade dried soxhlet extracts. Activity was most prominent after 2 hours of decoction. MIC and MBC were 625#g/ml each against S. aureus and 1250#g/ml and 2500#g/ml respectively for E. coli. The plants were shown to have ample quantities of saponins, flavonoids and alkaloids. No particular pattern was established in the antibacterial activity and hence no standard protocol could be suggested. The level of phytochemical compounds Neem contains is a pointer to the usefulness of the plant as a credible and cheap alternative for antibiotics considering its abundance and availability.