The occurrence, diversity and antibiogram of the pathogenic bacteria were investigated from samples collected from abattoir effluent, cow dung, raw meat and meat selling table swab, in Akim, Anantigha and Ibesikpo abattoirs, Calabar metropolis. Results obtained revealed that the mean heterotrophic bacterial counts ranged from 2.16 × 10 to 6.80 × 10 cfuml g . The bacterial genera isolated and identified included (15.4%), (15.4%), (10.2%), (2.6%) and (2.6%) while the Gram negative were 53.7% and included (20.5%), (12.8%), (7.7%), (7.7%) and (5.1%). The Antibiotic susceptibility screening of these organisms on broad spectrum antibiotics revealed multiple resistance approximately 50.6% and significant (P 0.05) among Gram negative isolates. The percentage sensitivity profile of the bacteria isolates ranged between 20.8% to Ampiclox and 79.2% to treptomycin for Gram positive bacteria, and 25.0% to Amoxil and 81.3% to Streptomycin for Gram negative bacteria. The study therefore, indicates that the risk of consumption of contaminated meat from abattoir is high. However, it is concluded that these associated public health problems can primarily be controlled by good sanitation and hygienic practice by stakeholders. Secondly, the use of antibiotics should be controlled and administered only by authorized personnel in the public health sector to reduce multiple drug resistance problems currently affecting our society.